SHI-YAN NG, Ph.D
Principal Investigator
Shi-Yan is a Principal Scientist at the Institute of Molecular and Cell Biology (Singapore), and Assistant Professor at the National University of Singapore, Department of Physiology.
Dr Ng received both her B.Sc (1st class honours) and Ph.D from the National University of Singapore. Her scientific career begun when she joined the laboratory of Dr. Lawrence Stanton at the Genome Institute of Singapore as a Ph.D student. During her Ph.D, she identified a novel class of regulatory RNAs – long non-coding RNAs – that are crucial for the maintenance of human embryonic stem cell pluripotency and elucidated the molecular function of some of these RNAs that are important for neuronal differentiation. In 2012, she started her postdoctoral training in the lab of Professor Lee Rubin at Harvard University, focusing on elucidating aberrant pathways in diseased neurons derived from patient-derived induced pluripotent stem cells, and targeting these pathways for therapeutic purposes.
Dr. Ng has received a number of awards including the National Research Foundation Fellowship (2018), A*STAR International Fellowship (2012) and Merck Millipore Young Scientist Award (2011).
Visit her Google Scholar page here.
SHERYLIN HOR
Ph.D Candidate
I unravel science mysteries by day and become an avid novel reader by night.
My current research interests focus on using iPSC-derived motor neurons to study motor neuron diseases (MNDs), particularly Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS). For SMA, we focus on investigating the role of SMN depletion in motor neuron survival and are interested in identifying potential therapeutic drugs that can enhance SMA motor neuron survival. For ALS, our main focus is to study the role of mitochondria dysfunction in ALS disease progression of motor neurons. Given the similarities in clinical manifestations of sporadic and familial ALS, we also hypothesize that there must be a common pathogenic mechanism in which mitochondria dysfunction plays a role in the degeneration of ALS motor neurons. If that is true, correction of this mitochondria defect could be developed into an effective treatment for both familial and sporadic ALS.
YONG HUI KOH
Ph.D Candidate
MUNIRAH MOHAMAD SANTOSA
Ph.D Candidate
SHARON LOH, Ph.D
Research Fellow
LI YI TAN, M.Sc
Research Officer
WINANTO
Research Officer
VALERIE LIM
Intern Student
ALUMNI of SYN LAB
Esther Hui Na Tan (currently PhD candidate at NUS)
Chih Sheng New
Shuhailah Salim
Eunice Shiyi Soh
Eugene Kwa (current A*STAR scholar)
Marinos Sotiropoulos (Medical student at National and Kapodistrian University of Athens, Greece)
Sharmini Rathakrishnan (Medical student at University College Dublin)
M Ganeshkumar
Kei Onn Lai